Cell BiologybioRxiv
PGC-1α regulates mitochondrial calcium homeostasis, SR stress and cell death to mitigate skeletal muscle aging
J. F. Gill, J. Delezie, G. Santos…·C. Handschin
This study shows that PGC-1α improves mitochondrial function and reduces sarcoplasmic reticulum stress and cell death in aging skeletal muscle, thereby delaying aging effects.
DOI 10.1111/acel.12993