Author

J. Farr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:electrophysiology· 2 Organism:human· 2 Research Focus:variant effect prediction· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. P. Hill· 2 shared C. A. Ng· 2 shared J. I. Vandenberg· 2 shared B. M. Kroncke· 1 shared D. Monroe· 1 shared D. Saul· 1 shared D. W. Mitchell· 1 shared E. Atkinson· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

A. P. Hill

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Author profile →

3 papers

Recent·Most cited

In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

P. Samakkarnthai, D. Saul, L. Zhang, Z. Aversa, M. L. Doolittle, J. Sfeir, J. Kaur, E. Atkinson, J. Edwards, G. Russell, R. Pignolo, J. Kirkland, T. Tchkonia, L. Niedernhofer, D. Monroe, , S. Khosla

This study shows zoledronate kills senescent cells in vitro and reduces SASP markers in vivo, suggesting potential senolytic and senomorphic effects.

Aging · May 7, 2023Peer-reviewedPhysiology

A Massively Parallel Trafficking Assay Accurately Predicts Loss of Channel Function in KCNH2 Variants

C. A. Ng, R. Ullah, J. Farr, A. P. Hill, K. A. Kozek, L. R. Vanags, D. W. Mitchell, B. M. Kroncke, J. I. Vandenberg

The paper develops a trafficking assay to predict KCNH2 variant function, showing high accuracy in classifying loss-of-function variants compared to existing methods.

bioRxiv · Jul 10, 2021Biophysics

Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology

C. A. Ng, J. Farr, P. Young, M. J. Windley, M. D. Perry, A. P. Hill, J. I. Vandenberg

This paper describes a high-throughput method to phenotype KCNH2 variants using automated patch-clamp electrophysiology and Flp-In HEK293 cells, enabling rapid assessment of variant function.

bioRxiv · Feb 2, 2021Biophysics