J. Kaur

Synovial fluid transcriptome dynamics in osteoarthritis progression: Implications in pathogenesis

This study identifies gene expression changes and pathways involved in osteoarthritis progression using synovial fluid transcriptomes from different OA grades.

Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in Black American and White American patients with TNBC

This study uses spatial omics to identify distinct tumor microenvironment profiles in Black and White American TNBC patients, linking them to different immunosuppressive mechanisms and clinical outcomes.

SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo

The paper shows that SARS-CoV-2 spike antibodies can enhance DENV2 infection in vitro and in vivo, suggesting potential for increased dengue severity in COVID-19 survivors.

Development of Fully Human, Bispecific Antibodies that Effectively Block Omicron Variant Pseudovirus Infections

This study develops fully human bispecific antibodies that effectively block Omicron variant pseudovirus infections, showing improved neutralization compared to monoclonal antibodies.

In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

This study shows zoledronate kills senescent cells in vitro and reduces SASP markers in vivo, suggesting potential senolytic and senomorphic effects.

Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

The paper uses CyTOF to identify senescent mesenchymal cells in aged mice, finding CD24+ osteolineage cells as targets for senolytic therapy.

A chromosome-scale assembly of Brassica carinata (BBCC) accession HC20 containing resistance to multiple pathogens and an early generation assessment of introgressions into B. juncea (AABB)

The paper presents a chromosome-scale genome assembly of B. carinata and assesses introgression potential into B. juncea for disease resistance.

Surface glia predominantly contribute to the development of ALS/FTD in Drosophila model

The paper shows surface glia are key in C9orf72-mediated ALS/FTD in Drosophila using genetic tools to mark glial subtypes.

Identification of a suitable endogenous control miRNA in bone aging and senescence

The paper identifies Let-7f as a stable endogenous control miRNA for normalizing miRNA expression in bone aging and senescence, showing improved accuracy compared to U6.

Mucin-mimetic action of capsaicin improves high fat diet-induced gut barrier dysfunction in mice colon

This study investigates how capsaicin affects gut barrier function and mucus production in mice, finding that it improves gut barrier integrity and microbial diversity through TRPV1 and mucus-related mechanisms.

IRC3 regulates mitochondrial translation in response to metabolic cues in Saccharomyces cerevisiae

The paper shows IRC3 regulates mitochondrial translation in response to metabolic cues in yeast by affecting mRNA translation rates under different carbon sources.

Megakaryopoiesis in Dengue virus infected K562 cell promotes viral replication which inhibits endomitosis and accumulation of ROS associated with differentiation

This study shows that DENV replication in PMA-induced differentiated K562 cells suppresses ROS accumulation and interferes with Megakaryopoiesis markers.

Gene expression pattern of vacuolar-iron transporter-like (VTL) genes in hexaploid wheat during metal stress

This study characterizes VTL genes in hexaploid wheat, showing their expression patterns under metal stress and their potential role in metal homeostasis.

CpG-creating Mutations are Costly in Many Human Viruses

The paper examines the cost of CpG-creating mutations in various human viruses using existing genomic data and finds they are generally costly.

Integrative analysis of hexaploid wheat roots identifies signature components during iron starvation

This study identifies gene and metabolic signatures in hexaploid wheat roots under iron starvation, revealing key transporters and metabolites involved in Fe acquisition and response.

Overlapping transcriptional expression response of wheat zinc-induced facilitator-like transporters emphasize important role during Fe and Zn stress

The paper identifies and analyzes wheat ZIFL transporters, showing their differential expression under Fe and Zn stress and heavy metal exposure.

ROS accumulation and associated cell death mediates susceptibility to Alternaria brassicae in Arabidopsis accessions

The paper investigates resistance mechanisms in Arabidopsis to Alternaria brassicae, finding that ROS accumulation and cell death correlate with susceptibility, and that RBOH D, E, F and JA/ET/ABA pathways influence defense.