Cancer BiologyJournal for ImmunoTherapy of CancerPeer-reviewed
MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer
M. Prasad, J. Zorea, S. Jagadeeshan…·M. Elkabets
This study shows that MEK1/2 inhibition temporarily improves the tumor immune microenvironment, enhancing immunotherapy effectiveness in head and neck cancer by reducing suppressive myeloid cells and boosting CD8+ T cell activity.
DOI 10.1136/jitc-2021-003917