Author

J. Fontana

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 3 Assay:cryo-EM· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:Drosophila· 1

Frequent Co-Authors

A. B. Shaw· 3 shared H. N. Tse· 3 shared J. N. Barr· 3 shared O. Byford· 3 shared A. Moon-Walker· 2 shared B. Alvarez-Rodriguez· 2 shared E. O. Saphire· 2 shared J. Barr· 2 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersMicrobiology

A. B. Shaw

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Organisation of the orthobunyavirus tripodal spike and the structural changes induced by low pH and K+ during entry

S. Hover, F. Charlton, J. Hellert, J. Barr, J. Mankouri, J. Fontana

The paper uses cryo-EM and AlphaFold to model the BUNV spike and shows how low pH and high K+ induce structural changes in the glycoproteins to facilitate entry.

Nature Communications · Sep 21, 2023Peer-reviewedMicrobiology

Exploiting the Affimer platform against influenza A virus

O. Debski-Antoniak, A. Flynn, D. P. Klebl, C. Tiede, I. A. Wilson, S. P. Muench, D. Tomlinson, J. Fontana

This paper isolates and characterizes Affimers, antibody-like proteins, that inhibit influenza A virus H3 subtype infection in vitro and block HA-receptor interactions.

bioRxiv · Aug 22, 2023Microbiology

Lymphocytic choriomeningitis arenavirus utilises tunnelling nanotube-like intercellular connections for cell-to-cell spread

O. Byford, A. B. Shaw, H. N. Tse, A. Moon-Walker, E. O. Saphire, S. P. J. Whelan, M. Stacey, R. Hewson, J. Fontana, J. N. Barr

This paper shows LCMV spreads between cells via tunnelling nanotube-like structures, bypassing extracellular transmission.

bioRxiv · Jun 28, 2023 · PreprintMicrobiology

Lymphocytic choriomeningitis arenavirus requires cellular COPI and AP-4 complexes for efficient replication and virion production.

O. Byford, A. B. Shaw, H. N. Tse, E. J. A. A. Todd, B. Alvarez-Rodriguez, R. Hewson, J. Fontana, J. N. Barr

This study identifies COPI and AP-4 cellular complexes as essential for LCMV replication and virion production, acting in late stages of the viral life cycle.

bioRxiv · Jun 27, 2023Microbiology

Cellular endosomal potassium ion flux regulates arenavirus uncoating during virus entry

A. B. Shaw, H. N. Tse, O. Byford, g. plahe, A. Moon-Walker, E. O. Saphire, S. P. J. Whelan, J. Mankouri, J. Fontana, J. N. Barr

This study identifies potassium ion flux as a third requirement for LCMV entry, showing it facilitates uncoating by modulating NP/Z interactions.

bioRxiv · Jun 23, 2023Cell Biology

The structure of a native orthobunyavirus ribonucleoprotein reveals a key role for viral RNA in maintaining its helical architecture

F. Hopkins, B. Alvarez-Rodriguez, G. Heath, K. Panayi, S. Hover, T. A. Edwards, J. Barr, J. Fontana

This paper determines the 3D structure of a native bunyavirus ribonucleoprotein (RNP) using cryo-EM, revealing a helical architecture stabilized by RNA rather than longitudinal contacts between nucleoprotein monomers.

bioRxiv · Oct 27, 2021 · PreprintMicrobiology

Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching

T. S. Hopes, K. Norris, M. Agapiou, C. G. McCarthy, P. A. Lewis, M. J. O'Connell, J. Fontana, J. L. Aspden

The paper characterizes ribosome heterogeneity in Drosophila melanogaster gonads, showing paralog-switching contributes to specialized ribosome populations that may regulate translation.

bioRxiv · Jan 20, 2020Biochemistry