J. Barr

Induced degradation of SNAP-fusion proteins

This paper develops SNAP-PROTACs to induce degradation of SNAP-fusion proteins, enabling selective depletion and functional analysis of target proteins.

Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a male mouse model of head-and-neck cancer

This study shows tumor-infiltrating nerves alter brain circuits and behavior in a male mouse model of head-and-neck cancer by changing neural activity and behavior.

EGFR-to-Src family tyrosine kinase switching in proliferating-DTP TNBC cells creates a hyperphosphorylation-dependent vulnerability to EGFR TKI

This study identifies a hyper-phosphorylation state in drug-resistant TNBC cells caused by EGFR-to-Src kinase switching, making them vulnerable to EGFR TKI treatment.

Context-dependent functions of mitochondria protein quality control in lung

This study shows that mitochondrial protein quality control via LONP1 is context-dependent in lung epithelial cells, affecting proliferation, differentiation, and migration through the integrated stress response.

Organisation of the orthobunyavirus tripodal spike and the structural changes induced by low pH and K+ during entry

The paper uses cryo-EM and AlphaFold to model the BUNV spike and shows how low pH and high K+ induce structural changes in the glycoproteins to facilitate entry.

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair

The paper identifies heterogeneous tuft cells in injured lungs that develop independently of Type 2 cytokines and are not essential for dysplastic repair.

The structure of a native orthobunyavirus ribonucleoprotein reveals a key role for viral RNA in maintaining its helical architecture

This paper determines the 3D structure of a native bunyavirus ribonucleoprotein (RNP) using cryo-EM, revealing a helical architecture stabilized by RNA rather than longitudinal contacts between nucleoprotein monomers.

Mapping the Central and Peripheral Projections of Lung Innervating Sensory Neurons

The paper maps the central and peripheral projections of lung-innervating sensory neurons, identifying their targets and marker expression.

Temporal stability and genetic diversity of 48-year old T-series phages

This study compares genetic stability of T-series phages over 48 years, finding limited genomic changes but no phenotypic differences between sublines.

Global phylogeography and ancient evolution of the widespread human gut virus crAssphage

This study investigates the origin, evolution, and epidemiology of crAssphage, a widespread human gut virus, using global DNA sequences showing local phylogeographic clustering and ancient primate associations.