J. W. Leiding

This study finds that larger primates exhibit stronger transcriptomic immune responses to bacterial sepsis, supporting the Safety Factor hypothesis over the Metabolic Theory of Ecology.

This study shows that STAT3 gain-of-function mutations in leukemia drive autoimmune pathology by causing NKG2Dhi CD8 T cell oligoclonal expansion and cytotoxic activity.

This study shows that overactive STAT3 leads to the accumulation of disease-associated CD21low B cells in both humans and mice.

This study shows that NOX2-derived reactive oxygen species are essential for CD8+ T cell effector function by promoting T-bet expression and mTOR complex 1 activation.

This study shows that ruxolitinib partially restores NK cell function in STAT1 GOF patients by reducing STAT1 phosphorylation and improving cytotoxic activity.