Author

J. Heth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. de Carvalho· 1 shared A. Rao· 1 shared A. Rehemtulla· 1 shared A. Taher· 1 shared C. Gao· 1 shared C. Speers· 1 shared D. Hambardzumyan· 1 shared D. Orringer· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. de Carvalho

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Author profile →

2 papers

Recent·Most cited

Subclonal evolution and expansion of THY1-positive cells is associated with recurrence in glioblastoma

W. N. Al-Holou, H. Wang, V. Ravikumar, M. Oneka, R. Verhaak, H. Kim, D. Pratt, S. Camelo-Piragua, C. Speers, D. Wahl, S. Shankar, T. Hollon, O. Sagher, J. Heth, K. Muraszko, , A. Rehemtulla

This paper identifies THY1-positive, mesenchymal/stem-like cells as drivers of glioblastoma recurrence and shows that targeting TGFβ signaling can restore sensitivity to therapy.

bioRxiv · Sep 10, 2021Cancer Biology

G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT

M. S. Alghamri, R. Avvari, R. Thalla, N. Kamran, L. Zhang, M. Ventosa, A. Taher, S. Faisal, F. Nunez, M. Garcia-Fabiani, S. Haase, S. Carney, D. Orringer, S. Hervey-Jumper, J. Heth, , M. G. Castro

The paper shows that mIDH1 glioma stem cells secrete G-CSF, which reprograms myeloid cells to become non-immunosuppressive, altering the tumor microenvironment.

bioRxiv · Jul 22, 2020 · PreprintCancer Biology