Cell BiologybioRxiv
The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis
J. Holloway, R. C. Turkington, D. B. Longley, E. Evergren
This study shows that Itch regulates TRAIL-mediated apoptosis by controlling TRAIL-R2 localization and mitochondrial cholesterol trafficking in oesophageal cancer cells.
DOI 10.1038/s41419-023-06417-4