Author

J. J. W. Han

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

C.-S. Lee· 1 shared J. Luo· 1 shared M. A. Keats· 1 shared Y.-H. Lee· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperCancer Biology

C.-S. Lee

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintDec 16, 2022

A non-conserved histidine residue on KRAS drives paralog selectivity of the KRAS G12D inhibitor MRTX1133

M. A. Keats, J. J. W. Han, Y.-H. Lee…·J. Luo

This study identifies histidine 95 as a key determinant of KRAS selectivity for the inhibitor MRTX1133, showing it binds specifically to KRAS but not HRAS or NRAS.

DOI 10.1101/2022.12.16.520846

humanproteomics

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