Y.-H. Lee

Cross-institutional HER2 assessment via a computer-aided system using federated learning and stain composition augmentation

This paper develops a HER2 assessment system using federated learning and stain composition augmentation, achieving over 90% accuracy across two institutions with improved generalizability.

Genetic and transcriptomic analysis of hyphal constriction based on a novel assay method in the rice blast fungus

The paper introduces an in vitro assay to study hyphal constriction in Magnaporthe oryzae, identifying transcriptional changes and a potential histone modification role in this process.

Dose-response relationship for the resistance of human insulin to degradation by insulin-degrading enzyme

The paper investigates how human insulin resistance to degradation by IDE varies with dose and identifies structural features of the insulin hexamer that influence degradation kinetics without zinc.

A non-conserved histidine residue on KRAS drives paralog selectivity of the KRAS G12D inhibitor MRTX1133

This study identifies histidine 95 as a key determinant of KRAS selectivity for the inhibitor MRTX1133, showing it binds specifically to KRAS but not HRAS or NRAS.

SARS-CoV-2 ORF8 limits expression levels of Spike antigen.

This study identifies ORF8 as a SARS-CoV-2 protein that reduces Spike antigen levels on infected cells, thereby limiting antibody recognition and immune evasion.

Adolescent parvalbumin expression in the left orbitofrontal cortex shapes sociability in female mice

This study shows that adolescent social isolation in female mice leads to increased sociability, reduced parvalbumin expression, and decreased social sniffing activity in the left orbitofrontal cortex, highlighting the role of PV+ inhibitory circuits in shaping female social behavior.

Structure of cyanobacterial photosystem I complexed with Cytochrome c6 and Ferredoxin at 1.97 A resolution

The paper presents a high-resolution cryo-EM structure of cyanobacterial photosystem I complexed with Cytochrome c6 and Ferredoxin, revealing binding interactions and a proposed electron transfer mechanism.

Exploring ensemble structures of Alzheimer's amyloid β (1-42) monomer using linear regression for the MD simulation and NMR chemical shift

This paper uses linear regression with NMR and MD simulation data to determine ensemble structures of Alzheimer's Aβ monomers, revealing β-sheet and partially-helical conformations and their implications for amyloidogenesis.

Dual effects of presynaptic membrane mimetics on α-synuclein amyloid aggregation

This study investigates how different membrane types affect α-synuclein aggregation, finding that presynaptic mimetic membranes have a dual effect on amyloid formation.

The glycosphingolipid inhibitor eliglustat inhibits autophagy in osteoclasts to increase bone mass and reduce myeloma bone disease

Eliglustat inhibits autophagy in osteoclasts, reducing MM bone disease and suggesting its use as a treatment for bone loss disorders.

A unique adhesive motif of protein disulfide isomerase P5 supports its function via dimerization

This study identifies a unique adhesive motif in P5 that enables dimerization, which is essential for its structural stability and functional roles in ER quality control.

Small Molecule Induced Toxic Human-IAPP Species Characterized by NMR

This study shows CurDAc inhibits hIAPP aggregation and disaggregates fibers, producing a toxic oligomer.

DeepIS: deep learning framework for three-dimensional label-free tracking of immunological synapses

This paper introduces a deep learning framework for 3D label-free tracking of immunological synapses using optical diffraction tomography and segmentation.

Unique unfoldase/aggregase activity of a molecular chaperone that dysregulates a translational elongation factor

This study shows Hsp33's non-canonical unfoldase/aggregase activity causes EF-Tu aggregation and degradation under heat stress, impacting cell survival.

Wavelength-encoded laser particles for massively-multiplexed cell tagging

This paper introduces laser particles for multiplexed cell tagging and imaging, demonstrating their stability, biocompatibility, and ability to track individual cells in 3D tumor models.

Zinc Boosts EGCG’s hIAPP Amyloid Inhibition Both in Solution and Membrane

This study shows that zinc enhances EGCG's ability to inhibit hIAPP amyloid aggregation both in solution and in the presence of lipid membranes.

Multiple reference genome sequences of hot pepper reveal the massive evolution of plant disease resistance genes by retroduplication

The paper reports multiple pepper genomes and finds that retroduplication via LTR-retrotransposons drives expansion of disease resistance genes in plants.