C.-S. Lee

Optimising CNT-FET Biosensor Design: Predictive Modelling of Biomolecular Electrostatic Gating and its Application to Beta-Lactamase Detection

This study models protein electrostatic interactions with CNT-FETs and demonstrates detection of beta-lactamases using BLIP2 receptors.

A non-conserved histidine residue on KRAS drives paralog selectivity of the KRAS G12D inhibitor MRTX1133

This study identifies histidine 95 as a key determinant of KRAS selectivity for the inhibitor MRTX1133, showing it binds specifically to KRAS but not HRAS or NRAS.

New Genotypes and Diversity of Orientia tsutsugamushi Isolated from Scrub Typhus Patients in South Korea as Determined by Multilocus Sequence Typing

This study identifies new genotypes of Orientia tsutsugamushi from South Korean scrub typhus patients using MLST, finding 10 new alleles and six novel sequence types, with ST48 being the most prevalent.

Visual Biochemistry: modular microfluidics enables kinetic insight from time-resolved cryo-EM

This paper introduces a time-resolved cryo-EM method using modular microfluidics to visualize biochemical reactions at near-atomic resolution and millisecond timescales, demonstrating its application to RecA filament formation.

Robust and sensitive detection of SARS-CoV-2 using PCR based methods

This study compares qPCR and ddPCR for SARS-CoV-2 detection, finding ddPCR more sensitive and accurate in quantifying viral RNA from various sources.

Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination

The paper shows that locus contraction and V(D)J recombination are regulated by circumventing CBE scanning impediments through Wapl-dependent cohesin dynamics.