Author

J. Khalife

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:plant (other)· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Farce· 2 shared I. C. Guerrera· 2 shared I. Metatla· 2 shared A. Cabezas-Cruz· 1 shared A. Chowdhury· 1 shared A. Dona· 1 shared A. Krishnan· 1 shared A. Martoriati· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

A. Farce

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHC CII complexes

Z. Qiu, J. Khalife, A.-P. Lin, P. Ethiraj, C. Jaafar, L. Chiou, G. Huelgas-Morales, S. Aslam, S. Arya, Y. Gupta, P. Dahia, R. Aguiar

This study shows that IRF8 mutations in DLBCL lymphomas impair antigen processing and presentation by reducing CD74 and HLA-DM, leading to immune evasion and increased tumor burden.

bioRxiv · Oct 14, 2023Cancer Biology

Characterization of the Plasmodium berghei regulatory AAA-ATPase subunit Rpt3 as an activator of Protein Phosphatase 1: direct and indirect evidence

C. Laine, C. De Witte, A. Martoriati, A. Farce, I. Metatla, I. C. Guerrera, K. Cailliau, J. Khalife, C. Pierrot

This paper characterizes PbRpt3 as an activator of Protein Phosphatase 1 in Plasmodium berghei, showing direct and indirect interactions through mutagenesis and Xenopus oocyte models.

bioRxiv · Jul 20, 2023 · PreprintMicrobiology

Characterization of GEXP15 as a potential regulator of Protein Phosphatase 1 and partner of ribosomal complex in Plasmodium falciparum.

H. Mansour, A. Cabezas-Cruz, V. Peucelle, A. Farce, S. Salome-Desnoulez, I. Metatla, I. C. Guerrera, T. Hollin, J. Khalife

This study identifies GEXP15 as a regulator of PP1 and ribosomal complex in Plasmodium falciparum, enhancing PP1 phosphatase activity and suggesting it as a drug target.

bioRxiv · Jul 4, 2023 · PreprintMicrobiology

Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting

D. Viola, A. Dona, E. Caserta, E. Troadec, E. G. Gunes, F. Besi, T. McDonald, L. Ghoda, J. F. Sanchez, J. Khalife, M. Martella, C. Karanes, M. Htut, X. Wang, M. Rosenzweig, , F. Pichiorri

This study shows that daratumumab targets CD38+ NK cells to induce immune activation and anti-myeloma activity despite reducing total NK cell frequency.

bioRxiv · Nov 22, 2019Cancer Biology

Rab11A regulates the constitutive secretory pathway during Toxoplasma gondii invasion of host cells and parasite replication.

K. Venugopal, S. Chehade, E. Werkmeister, N. Barois, J. Periz, F. Lafont, I. Tardieux, J. Khalife, G. Langsley, M. Meissner, S. MARION

This study identifies Rab11A's role in constitutive secretion and cargo transport during Toxoplasma gondii invasion and replication, revealing its impact on parasite motility and virulence.

bioRxiv · Sep 25, 2019Microbiology