Author

T. Hollin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Organism:plant (other)· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

K. G. Le Roch· 4 shared S. Abel· 4 shared J. Prudhomme· 3 shared A. Saraf· 2 shared C. Banks· 2 shared G. Batugedara· 2 shared L. Florens· 2 shared T. Lenz· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersMicrobiology

K. G. Le Roch

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Author profile →

5 papers

Recent·Most cited

MicrobiologybioRxivPreprintNov 21, 2023

A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in P. falciparum Malaria.

Z. M. Chahine, S. Abel, T. Hollin…·K. G. Le Roch

This paper identifies MED6-189, a potent antimalarial compound that disrupts apicoplast function and vesicular trafficking in P. falciparum, showing efficacy against drug-resistant strains and demonstrating a unique mechanism of action.

DOI 10.1101/2023.11.21.568162

humanexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivSep 11, 2023

PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

Z. M. Chahine, M. Gupta, T. Lenz…·K. G. Le Roch

This study shows PfMORC regulates chromatin structure and gene repression in Plasmodium falciparum, essential for parasite survival and a potential target for antimalarial drugs.

DOI 10.7554/elife.92499

humanChIP-seq

𝕏 PostBluesky

MicrobiologybioRxivPreprintJul 4, 2023

Characterization of GEXP15 as a potential regulator of Protein Phosphatase 1 and partner of ribosomal complex in Plasmodium falciparum.

H. Mansour, A. Cabezas-Cruz, V. Peucelle…·J. Khalife

This study identifies GEXP15 as a regulator of PP1 and ribosomal complex in Plasmodium falciparum, enhancing PP1 phosphatase activity and suggesting it as a drug target.

DOI 10.1101/2023.07.04.547663

plant (other)proteomics

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MicrobiologybioRxivPreprintOct 12, 2022

Deciphering the non-coding code of pathogenicity and sexual differentiation in the human malaria parasite.

G. Batugedara, X. M. Lu, S. Abel…·K. G. Le Roch

This study identifies and characterizes long non-coding RNAs (lncRNAs) in Plasmodium falciparum, revealing their role in gene regulation, pathogenicity, and sexual differentiation.

DOI 10.1101/2022.10.12.511630

humanbulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivDec 22, 2019

Plasmodium condensin core subunits (SMC2/SMC4) mediate atypical mitosis and are essential for parasite proliferation and transmission

R. Pandey, S. Abel, M. Boucher…·R. Tewari

DOI 10.1016/j.celrep.2020.01.033

plant (other)ChIP-seq

𝕏 PostBluesky