Author

S. Aslam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:bacteria (other)· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

A. Garcia-Sastre· 3 shared A. S. Gonzalez-Reiche· 2 shared E. M. Sordillo· 2 shared H. van Bakel· 2 shared I. Mena· 2 shared L. Zuliani-Alvarez· 2 shared M. Laporte· 2 shared R. Rathnasinghe· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

A. Garcia-Sastre

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Author profile →

9 papers

Recent·Most cited

IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHC CII complexes

Z. Qiu, J. Khalife, A.-P. Lin, P. Ethiraj, C. Jaafar, L. Chiou, G. Huelgas-Morales, S. Aslam, S. Arya, Y. Gupta, P. Dahia, R. Aguiar

This study shows that IRF8 mutations in DLBCL lymphomas impair antigen processing and presentation by reducing CD74 and HLA-DM, leading to immune evasion and increased tumor burden.

bioRxiv · Oct 14, 2023Cancer Biology

A simple solid media assay for detection of synergy between bacteriophages and antibiotics

E. Khong, J. Oh, J. M. Jiminez, R. Liu, S. J. B. Dunham, A. Monsibais, A. Rhoads, P. Ghatbale, A. Garcia, A. G. Cobian-Güemes, A. Blanc, M. Chiu, P. Kuo, M. Proost, A. Kline, , D. T. Pride

The paper develops a solid media assay to assess synergistic interactions between antibiotics and bacteriophages, identifying synergistic effects across diverse bacterial isolates.

bioRxiv · Aug 23, 2023Microbiology

Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian Hamsters

J. Garcia-Bernalt Diego, G. Singh, S. Jangra, K. Handrejk, M. Laporte, L. A. Chang, S. S. El Zahed, L. Pache, M. W. Chang, P. Warang, S. Aslam, I. Mena, B. T. Webb, C. Benner, A. Garcia-Sastre, M. Schotsaert

This study evaluates hybrid immunity in mRNA-vaccinated hamsters during breakthrough infections, finding enhanced cross-reactive immune responses despite low neutralizing antibody titers.

bioRxiv · May 22, 2023Microbiology

Diversified repertoire of phage resistance in Klebsiella pneumoniae and bidirectional steering effects impacting antibiotic susceptibility

S. C. Nang, J. Lu, H. H. Yu, H. Wickremasinghe, M. A. K. Azad, M. Han, J. Zhao, G. Rao, P. J. Bergen, T. Velkov, N. Sherry, D. T. McCarthy, S. Aslam, R. T. Schooley, B. P. Howden, , J. Li

The paper investigates phage resistance mechanisms in Klebsiella pneumoniae and shows how these can both increase and decrease antibiotic susceptibility.

bioRxiv · Nov 14, 2022 · PreprintMicrobiology

Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.

T. Kehrer, A. Cupic, C. Ye, S. Yildiz, M. Bouhhadou, N. A. Crossland, E. Barrall, P. Cohen, A. Tseng, T. Cagatay, R. Rathnasinghe, D. Flores, S. Jangra, F. Alam, N. Mena, , L. Miorin

This study shows SARS-CoV-2 ORF6 disrupts nucleo-cytoplasmic trafficking, inhibits IFN signaling, and modulates viral protein expression, with variant polymorphisms affecting its function.

bioRxiv · Oct 18, 2022Microbiology

Multi-site Performance Evaluation of the cobas 5800 System and Comparison to the cobas 6800/8800 Systems for Quantitative Measurement of HBV, HCV, and HIV-1 Viral Load.

J. Tschape, A. Cobernuss-Rahn, S. Boyle, N. T. Parkin, B. LaBrot, S. Aslam, S. Young, P. Gohl

This study compares the performance of the cobas 5800 system to the cobas 6800/8800 systems for viral load measurement of HBV, HCV, and HIV-1 across multiple sites, finding high correlation and acceptable variability.

bioRxiv · Aug 9, 2022Microbiology

SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage

A. Escalera, A. S. Gonzalez-Reiche, S. Aslam, I. Mena, R. L. Pearl, M. Laporte, A. Fossati, R. Rathnasinghe, H. Alshammary, A. van de Guchte, M. Bouhaddou, T. Kehrer, L. Zuliani-Alvarez, D. A. Meekins, V. Balaraman, , T. Aydillo

This study shows SARS-CoV-2 variants of concern have mutations that increase spike cleavage and fusogenic capacity, enhancing viral transmission and cell entry.

bioRxiv · Aug 5, 2021 · PreprintMicrobiology

Clinical Phage Microbiology:A suggested framework and recommendations for the in-vitro matching steps ‎of phage therapy

D. Gelman, O. Yerushalmy, S. Ben-Porat, C. Rakov, S. Alkalay-Oren, K. Adler, L. Khalifa, M. Abdalrhman, S. Coppenhagen-Glazer, S. Aslam, R. T. Schooley, R. Nir-Paz, R. Hazan

This paper proposes a framework for in vitro phage-antibiotic matching in clinical settings to support personalized phage therapy.

bioRxiv · Feb 23, 2021Microbiology

Aerobiosis is not associated with GC content and G to T mutations are not the signature of oxidative stress in prokaryotic evolution

S. Aslam, X.-R. Lan, B.-W. Zhang, Z.-L. Chen, D.-K. Niu

The paper examines the relationship between aerobiosis, GC content, and G to T mutations in prokaryotes, finding no significant association between oxygen requirement and GC content or mutation rates.

bioRxiv · May 19, 2018Evolutionary Biology