J. Kool

Pyocyanin produced by Pseudomonas aeruginosa Creates Legacy Effects That Boost Antibiotic Resistance Evolution in Enterococci

The paper shows that exposure to pyocyanin from Pseudomonas aeruginosa increases antibiotic resistance evolution in enterococci through efflux mechanisms.

An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules

This paper develops an in vitro assay to screen for venom neurotoxin activity on muscle-type nAChR and identify toxin-inhibitory molecules, showing robust assay performance across 96-well plates.

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

The paper shows repurposed drugs and their combinations reduce cytotoxicity of snake venoms in cell and mouse models, offering potential new treatments for snakebite envenoming.

In vitro and in vivo venom-inhibition assays identify metalloproteinase-inhibiting drugs as potential treatments for snakebite envenoming by Dispholidus typus

This study evaluates four SVMP inhibitors for treating D. typus snakebite envenoming, finding DMPS and marimastat effective in preclinical models.

Pathology and immunity after SARS-CoV-2 infection in male ferrets is affected by age and inoculation route

This study investigates how age and inoculation route affect SARS-CoV-2 infection and immunity in male ferrets, finding persistent inflammation and potential long-COVID-like features in young animals.

Asymptomatic gut colonization by extended-spectrum beta-lactamase-producing Escherichia coli is not associated with an altered gut microbiome or metabolome in Dutch adults

This study finds that asymptomatic gut colonization by ESBL-producing E. coli in Dutch adults is not linked to changes in microbiome or metabolome composition.

Neutralizing effects of small molecule inhibitors and metal chelators on coagulopathic Viperinae snake venom toxins

This study investigates the neutralizing effects of small molecule inhibitors and metal chelators on coagulopathic toxins in Viperinae snake venoms using chromatography, mass spectrometry, and bioassaying.

A combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite

This study shows that a combination of two small molecule inhibitors effectively neutralizes viper venom in vitro and prevents lethality in vivo across multiple regions.

Development of high-throughput screening assays for profiling snake venom Phospholipase A2 activity after high resolution chromatographic fractionation

The paper develops high-throughput assays to profile PLA2 activity in snake venoms after chromatographic fractionation, using absorbance and fluorescence detection methods.

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches

This study identifies coagulopathic snake venom proteins and peptides using nanofractionation and proteomics, revealing both procoagulant and anticoagulant toxins across multiple species.

Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite

This paper shows that the metal chelator DMPS can effectively treat hemotoxic snakebite in mice, both when given orally and in combination with antivenom.