Author

L. Ledsgaard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. H. Laustsen· 3 shared A. Karatt-Vellatt· 2 shared J. McCafferty· 2 shared P. Villar· 2 shared A. Ljungars· 1 shared B. G. Voldborg· 1 shared B. Lomonte· 1 shared C. Rimbault· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBioengineering

A. H. Laustsen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Phage display assisted discovery of a pH-dependent anti-alpha-cobratoxin antibody from a natural variable domain library

T. Ej Efternavn, R. W. Pedersen, C. Rimbault, S. Ahmadi, L. Ledsgaard, M.-F. Bohn, A. Ljungars, B. G. Voldborg, F. Ruso-Julve, J. T. Andersen, A. H. Laustsen

The paper discovers a pH-dependent anti-alpha-cobratoxin antibody from a natural variable domain library without histidine doping, showing that pH-dependency can arise without histidine residues.

bioRxiv · May 8, 2023Bioengineering

An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules

R. N. Patel, R. H. Clare, L. Ledsgaard, M. Nys, J. Kool, A. H. Laustsen, C. Ulens, N. R. Casewell

This paper develops an in vitro assay to screen for venom neurotoxin activity on muscle-type nAChR and identify toxin-inhibitory molecules, showing robust assay performance across 96-well plates.

bioRxiv · Apr 28, 2023 · PreprintPharmacology & Toxicology

Discovery of a broadly-neutralizing human antibody that can rescue mice challenged with neurotoxin-rich snake venoms

L. Ledsgaard, J. Wade, K. Boddum, I. Oganesyan, J. Harrison, T. P. Jenkins, P. Villar, R. A. Leah, R. Zenobi, J. McCafferty, B. Lomonte, J. M. Gutierrez, A. H. Laustsen, A. Karatt-Vellatt

This paper describes the discovery of a broadly-neutralizing human antibody effective against multiple snake venoms, demonstrating its therapeutic potential in mice.

bioRxiv · Jun 17, 2022 · PreprintBioengineering

Deep mining of early antibody response in COVID-19 patients yields potent neutralisers and reveals high level of convergence

G. Bullen, J. D. Galson, P. Villar, L. Moreels, L. Ledsgaard, G. Mattiuzzo, G. Hall, E. M. Bentley, E. W. Masters, D. Tang, S. Millett, D. Tongue, R. Brown, I. Diamantopoulos, K. Parthiban, , A. Karatt-Vellatt

The paper identifies potent neutralising antibodies from early COVID-19 patient samples and shows high convergence in antibody sequences across studies.

bioRxiv · Dec 29, 2020 · PreprintImmunology