Author

S. Lenz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Immunology· 1 Microbiology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:protein folding & dynamics· 3 Approach:biophysical modeling· 2 Organism:human· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

H. van Dijken· 3 shared J. de Jonge· 3 shared K. van de Ven· 3 shared C. V. B. de Melo· 2 shared F. Peters· 2 shared I. Bodnariuc· 2 shared J. L. MacCallum· 2 shared L. Wijsman· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

H. van Dijken

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

How important are concurrent vehicle control groups in (sub)chronic non-human primate toxicity studies conducted in pharmaceutical development? An opportunity to reduce animal numbers

L. Mecklenburg, S. Lenz, G. Hempel

This study evaluates the necessity of concurrent vehicle control groups in non-human primate toxicity studies and suggests alternatives to reduce animal use.

bioRxiv · Feb 15, 2023Pharmacology & Toxicology

A universal influenza mRNA vaccine candidate boosts T-cell responses and reduces zoonotic influenza virus disease in ferrets

K. van de Ven, J. Lanfermeijer, H. van Dijken, H. Muramatsu, C. V. B. de Melo, S. Lenz, F. Peters, M. B. Beattie, P. J. Lin, J. A. Ferreira, J. van den Brand, D. van Baarle, N. Pardi, J. de Jonge

This study evaluates a T-cell-inducing mRNA vaccine against influenza, showing it boosts T-cell responses and reduces disease in ferrets.

bioRxiv · Aug 2, 2022Immunology

Influenza infection in ferrets with SARS-CoV-2 infection history

C. V. B. de Melo, F. Peters, H. van Dijken, S. Lenz, K. van de Ven, L. Wijsman, A. Gommersbach, T. Schouten, P. B. van Kasteren, J. M. A. van den Brand, J. de Jonge

This study investigates whether prior SARS-CoV-2 infection affects influenza disease severity in ferrets, finding mild increased symptoms but no major histopathological changes.

bioRxiv · Mar 22, 2022 · PreprintPathology

Visualizing translation dynamics at atomic detail inside a bacterial cell

L. Xue, S. Lenz, M. Zimmermann-Kogadeeva, D. Tegunov, P. Cramer, P. Bork, J. Rappsilber, J. Mahamid

This study uses cryo-electron tomography to visualize translation dynamics in Mycoplasma pneumoniae, revealing ribosome states and showing how antibiotics affect translation.

bioRxiv · Dec 18, 2021Biochemistry

FABP7 Binds to Fatty Acid Micelles: Implications for Lipid Transport

S. Lenz, I. Bodnariuc, M. Renaud-Young, T. M. Shandro, J. L. MacCallum

This paper investigates how FABP7 binds to fatty acid micelles and provides structural insights into hydrophobic molecule transport.

bioRxiv · Oct 22, 2021 · PreprintBiophysics

Brain fatty acid binding protein exhibits non-preferential and mutation-resistant binding towards fatty acids

I. Bodnariuc, S. Lenz, M. Renaud-Young, T. M. Shandro, H. Ishida, H. J. Vogel, J. L. MacCallum

This study shows FABP7 binds fatty acids with similar affinities at physiological temperature, and nuclear localization depends on conformational changes rather than binding preference or mutations.

bioRxiv · Sep 23, 2021 · PreprintBiophysics

Pathology and immunity after SARS-CoV-2 infection in male ferrets is affected by age and inoculation route

K. van de Ven, H. van Dijken, L. Wijsman, A. Gomersbach, T. Schouten, J. Kool, S. Lenz, P. Roholl, A. Meijer, P. van Kasteren, J. de Jonge

This study investigates how age and inoculation route affect SARS-CoV-2 infection and immunity in male ferrets, finding persistent inflammation and potential long-COVID-like features in young animals.

bioRxiv · Jun 30, 2021Microbiology