A. H. Laustsen

VIDAL is a machine-learning tool that automatically analyzes dermonecrosis in mouse models to assess antivenom efficacy, offering an accurate and reproducible alternative to manual methods.

The paper discovers a pH-dependent anti-alpha-cobratoxin antibody from a natural variable domain library without histidine doping, showing that pH-dependency can arise without histidine residues.

This paper develops an in vitro assay to screen for venom neurotoxin activity on muscle-type nAChR and identify toxin-inhibitory molecules, showing robust assay performance across 96-well plates.

This study develops a high-throughput method to discover broadly-neutralizing antibodies against venom toxins using consensus antigens, showing improved success in cross-neutralization compared to traditional methods.

This paper describes a prototype lateral flow assay using monoclonal antibodies to detect Bothrops venoms, achieving a limit of detection of 8.0 ng/mL in serum and 9.5 ng/mL in urine.

This paper describes the discovery of a broadly-neutralizing human antibody effective against multiple snake venoms, demonstrating its therapeutic potential in mice.

This study shows that phospholipases A2 from Black-necked spitting cobra venom block Trypanosoma brucei endocytosis by enlarging the flagellar pocket and disrupting Rab11 localization, leading to cell cycle arrest.