M. Hale

Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice

The paper isolates PcrV-specific B cells from cystic fibrosis patients and generates monoclonal antibodies that reduce Pseudomonas aeruginosa burden in mice.

Mutation of two intronic nucleotide alters RNA structure and dynamics, inhibiting MBNL1 and RBFOX1 regulated splicing of the Insulin Receptor

The paper shows that mutating two intronic nucleotides alters RNA structure and dynamics, disrupting MBNL1 and RBFOX1 regulation of INSR exon 11 splicing.

MBNL1 and RBFOX1 co-regulate alternative splicing events transcriptome-wide through a conserved buffering mechanism

This study identifies a conserved buffering mechanism where MBNL1 and RBFOX1 co-regulate alternative splicing by overlapping RNA motifs, reducing the range of splicing outcomes.

Defining the cell surface proteomic landscape of multiple myeloma reveals immunotherapeutic strategies and biomarkers of drug resistance

This study defines the myeloma cell surface proteome, identifies therapeutic targets and resistance biomarkers, and presents a miniaturized surface proteomics protocol.

Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma

This study identifies allosteric HSP70 inhibitors that overcome proteasome inhibitor resistance in multiple myeloma by targeting mitochondrial HSPA9 and disrupting mitoribosome stability.

Disease Risk Analysis in sea turtles: A baseline study to inform conservation efforts

This study conducts a disease risk analysis for all seven sea turtle species, identifying knowledge gaps and suggesting management strategies for conservation.

Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite

This paper shows that the metal chelator DMPS can effectively treat hemotoxic snakebite in mice, both when given orally and in combination with antivenom.