A. K. Grosskopf

This paper develops a label-free RPLC-CAD method to analyze supramolecular hydrogel composition and drug payload, demonstrating its applicability for rheological and release kinetic studies.

This paper develops fluorescent KSHV strains and a hybrid RRV expressing KSHV gB to show low pH is required for KSHV membrane fusion during endocytosis.

This paper identifies Tim-1 and Tim-4 as mediators of KSHV and RRV entry, showing their role in viral infection and highlighting their unique function compared to other herpesviruses.

This study shows K8.1 is critical for KSHV infection in epithelial cells but not in B cells, functioning at the attachment step.

This paper develops an injectable polymer-nanoparticle hydrogel for sustained intravitreal delivery of bimatoprost, showing prolonged drug release and minimal inflammation in rabbits.

This paper develops injectable hydrogels to safely deliver CD40 agonist antibodies, reducing toxicity while maintaining anti-cancer efficacy in a melanoma model.

This paper introduces an amphiphilic copolymer excipient that enhances the stability of high-concentration monoclonal antibody formulations without affecting pharmacokinetics or injectability.

This study investigates how hydrogel rheological properties affect depot formation and persistence after subcutaneous injection in mice.

This paper develops an injectable hydrogel to co-deliver CAR-T cells and cytokines, enhancing solid tumor treatment in mice by creating a transient inflammatory niche.

This study shows that slow release of an RBD subunit vaccine via hydrogel enhances neutralizing antibody responses against SARS-CoV-2 compared to bolus administration.

This paper develops injectable liposomal hydrogels that enable the programmed release of multiple protein drugs in vivo.

This study identifies IFITM1 as a cell type-dependent inhibitor of KSHV and RRV infection, acting at the membrane fusion stage, and shows that HUVEC resist IFITM restriction despite high expression.

This paper introduces a hydrogel-based tumor inoculation method that reduces variability in murine tumor growth, enabling more efficient and reliable cancer studies.

This paper develops amphiphilic copolymers to enhance insulin formulation resilience, enabling storage without refrigeration for over 6 months and improving global access to insulin.

This study compares the requirements for receptor expression and proteolytic activation in SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion, revealing differences in their dependence on ACE2, TMPRSS2, and metalloproteases.

This study identifies Plxdc1/2 as novel receptors for RRV, distinguishing it from KSHV and highlighting a conserved N-terminal motif in RRV gH/gL.

This study develops combinatorial polyacrylamide hydrogels that outperform current anti-biofouling coatings in preventing biofouling on biosensors.

This paper identifies EphA7 as the critical receptor for KSHV cell-to-cell transmission into BJAB B cells and for RRV cell-free infection, showing functional conservation between these viruses.