J. L. Uhrlaub

This study develops low-copy hACE2 transgenic mice to better model SARS-CoV-2 infection, showing reduced mortality and viral spread compared to high-copy lines.

This study shows that lifelong cytomegalovirus and early-life irradiation together worsen age-related immune defects in response to vaccination and infection.

This study compares the effects of infection route and age on mCMV spread, immune responses, and latency in mice, finding age-related differences in immune activation and T cell responses.

This study shows that skin-draining lymph nodes atrophy early in mice, leading to impaired immune function and reduced effector cell production in older age.

This study shows older adults have robust cellular immunity and comparable neutralizing antibody responses to SARS-CoV-2 variants after mRNA vaccination.

This study shows that MAVS, an RLR signaling adaptor, is critical for the quality of the antibody response to WNV, as MAVS-deficient mice produced low-affinity IgM antibodies despite normal antigen levels.