R. Perera

Decorrelation Time Mapping as an Analysis Tool for Nanobubble-Based Contrast Enhanced Ultrasound Imaging

This paper introduces decorrelation time mapping to distinguish intravascular and extravascular nanobubble signals in ultrasound imaging, showing higher decorrelation times in tumor tissue compared to normal tissue.

Assessing Tumor Microenvironment Characteristics and Stratifying EPR with a Nanobubble Companion Nanoparticle via Contrast-Enhanced Ultrasound Imaging

This paper uses contrast-enhanced ultrasound imaging with nanobubbles to assess tumor microenvironment characteristics and predict nanoparticle distribution in tumors with different vascular permeability.

Pyrethroid susceptibility reversal in Aedes aegypti: a longitudinal study in Tapachula, Mexico

This study shows that stopping pyrethroid use in mosquitoes reduced their resistance over time, but resistance rebounded when pyrethroids were reintroduced.

Human sialidase activity is vital for dengue virus serotype 2 infection

This study shows that sialidase activity is essential for dengue virus serotype 2 replication and egress, and that NEU1-3 depend transcriptionally on NEU4.

Shifting a Cellular Metabolic Landscape Identifies a Refractory Environment for Flavivirus Replication

The paper identifies a refractory metabolic environment induced by fatty acid biosynthesis inhibition that limits flavivirus replication and shows that combining this with nucleotide synthesis pathway inhibition significantly reduces viral infectivity.

Expression of fatty acid synthase genes and their role in development and arboviral infection of Aedes aegypti

This study identifies and characterizes FAS genes in Aedes aegypti, showing AaFAS1's role in dengue virus infection and transmission.

RNase L-mediated RNA decay alters 3' end formation and splicing of host mRNAs

This study shows that RNase L-mediated RNA decay causes RNA-binding proteins to shift from cytoplasm to nucleus, altering splicing and 3' end formation of host mRNAs, especially interferons.

Acyl-CoA Thioesterases; a rheostat that controls activated fatty acids modulates dengue virus serotype 2 replication

This study investigates the role of acyl-CoA thioesterases (ACOTs) in modulating dengue virus serotype 2 replication, showing that their loss of function affects viral replication and infectious particle release.

Coupled small molecules target RNA interference and JAK/STAT signaling to reduce Zika virus infection in Aedes aegypti

This study shows that repurposed small molecules activate both RNA interference and JAK/STAT antiviral pathways in Aedes aegypti, significantly reducing Zika virus levels.

Intracellular Vesicle Entrapment of Nanobubble Ultrasound Contrast Agents Targeted to PSMA Promotes Prolonged Enhancement and Stability In Vivo and In Vitro

This study investigates how PSMA-targeted nanobubbles enhance ultrasound imaging in prostate tumors by being internalized and retained in intracellular vesicles, leading to prolonged signal and stability.

Rapid decay of host basal mRNAs during SARS-CoV-2 infection perturbs host antiviral mRNA biogenesis and export

This study shows SARS-CoV-2 infection inhibits IFN mRNA biogenesis and export by blocking nuclear-cytoplasmic transport and triggering mRNA degradation.

Surface-aerosol stability and pathogenicity of diverse MERS-CoV strains from 2012 - 2018

The paper examines the environmental stability, replication kinetics, and pathogenicity of diverse MERS-CoV strains and SARS-CoV-2, finding variation in stability and pathogenicity among isolates.

Triple Combination Nitazoxanide, Ribavirin, and Hydroxychloroquine results in the multiplicative reduction of in vitro SARS-CoV-2 viral replication

This study tests a triple drug combination for reducing SARS-CoV-2 replication in vitro, finding a significant multiplicative effect on virus yield and delayed cytopathic effects.

Development of SARS-CoV-2 Nucleocapsid Specific Monoclonal Antibodies

This study develops and characterizes mouse monoclonal antibodies specific to SARS-CoV-2 nucleocapsid protein, tested using ELISA, western blot, and immunofluorescence.

Lamin B2 follows lamin A/C- mediated nuclear mechanics and cancer cell invasion efficacy

The paper investigates the role of lamin B2 in nuclear mechanics and cancer cell invasion, finding that lamin B2 cooperates with lamin A/C to regulate nuclear deformability and migration efficacy.

Bubble Trouble: Conquering Microbubble Limitations in Contrast Enhanced Ultrasound Imaging by Nature-Inspired Ultrastable Echogenic Nanobubbles

This paper develops ultrastable nanobubbles for ultrasound imaging by engineering a dual-layer shell inspired by bacterial cell envelopes, improving in vivo stability and signal persistence.