Cell BiologybioRxiv
Regulation of Interorganellar Ca2+ Transfer and NFAT Activation by the Mitochondrial Ca2+ Uniporter
R. E. Yoast, S. M. Emrich, X. Zhang…·M. Trebak
This study investigates how mitochondrial Ca2+ uniporter (MCU) regulates interorganellar Ca2+ signaling and NFAT activation, showing that MCU-KO increases cytosolic Ca2+ despite reduced CRAC channel activity.
DOI 10.1016/j.jbc.2021.101174