D. I. Yule

This study outlines the architecture of Ca2+ tunneling, a Ca2+ signaling modality, and shows it is important for Cl- secretion in sweat glands.

The paper uses a modified aequorin probe to measure Ca2+ in endo-lysosomes, revealing IP3-sensitive Ca2+ stores and functional IP3 receptors in this compartment.

The paper presents a method for analyzing calcium signaling data using Jupyter-Lab notebooks with custom scripts to manage complexity and improve workflow efficiency.

The paper determines 3D structures of IP3R1 in two ligand-bound states using cryo-EM and identifies dynamic properties of key domains involved in ligand binding and channel gating.

The paper shows IP3Rs regulate neuronal SOCE through IP3 binding, independent of Ca2+ release, by enhancing STIM1-Orai1 association.

This study identifies acidic residues in IP3Rs critical for Ca2+ binding and activation, showing their role in modulating channel activity and Ca2+ sensitivity.

This study identifies IP3R-mediated local [Ca2+]ER decreases as the driver of immobile STIM2 clusters at ER-PM junctions, marking a checkpoint for SOCE initiation under sub-threshold stimuli.

This study shows that CREB regulates IP3R1 expression and localization, affecting Ca2+ release and puffs.

This study investigates how mitochondrial Ca2+ uniporter (MCU) regulates interorganellar Ca2+ signaling and NFAT activation, showing that MCU-KO increases cytosolic Ca2+ despite reduced CRAC channel activity.

The study observes localized Ca2+ signals in live mice that contradict previous in vitro models of salivary secretion and proposes a new mathematical model to explain the mechanism.

This paper shows that all five STIM1/2 and Orai1/2/3 isoforms, along with IP3R, work together in a graded manner to ensure precise and diverse Ca2+ signaling in mammals.