J. Marko

HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

This study shows HP1α crosslinks chromatin to maintain nuclear and mitotic chromosome mechanics, independent of histone methylation.

Single-Molecule Micromanipulation Studies Of Methylated DNA

This study uses single-molecule techniques to quantify how DNA methylation affects DNA flexibility and structural stability under physiological conditions.

Condensin controls mitotic chromosome stiffness and stability without forming a structurally contiguous scaffold

This study shows condensin controls mitotic chromosome stiffness and stability by forming isolated compaction centers rather than a continuous scaffold.

Receptor-ligand rebinding kinetics in confinement

This study examines ligand-receptor rebinding kinetics in confined environments, revealing scaling laws and time-dependent behavior under different diffusion and reaction-limited conditions.

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

The paper shows that chromatin histone modifications affect nuclear rigidity and morphology independently of lamins, inducing or suppressing nuclear blebs through changes in chromatin compaction.

Torque and buckling in stretched intertwined double-helix DNAs

This study develops a statistical-mechanical model to analyze torque and buckling in stretched intertwined DNAs, showing catenation-dependent behavior and predicting a buckling transition with a discontinuity in extension.