R. Goldman

This study identifies LG3BP as a binding partner of Sulf-2 in HNSCC and shows that LG3BP inhibits Sulf-2 activity, reducing HNSCC cell invasion.

This study shows that Sulf-2 promotes HNSCC cell invasion in co-cultures with CAFs, and a marine glycosaminoglycan inhibits this effect.

The paper identifies 'Ghost' fragment ions in glycoproteomics that can lead to false positive structure assignments and proposes a minimal intensity threshold to mitigate this issue.

The paper investigates SULF1 and SULF2 in HNSC and other cancers, finding SULF1 is secreted by fibroblasts and negatively impacts survival early, while SULF2, from tumor cells, affects survival later, with implications for therapy.

The paper introduces a workflow for quantifying IgG glycoforms using stable isotope labeled standards and LC-MS/MS-PRM, achieving high sensitivity and precision.

This study reveals that vimentin intermediate filaments and F-actin form an interpenetrating network in the cell cortex, enhancing contractile forces and influencing actin dynamics.

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

This study evaluates the immunogenicity of the mRNA vaccine MRT5500 in mice and non-human primates, showing it elicits neutralizing antibodies and TH1-biased responses.

This study quantifies core fucosylation changes in liver disease using mass spectrometry and exoglycosidase-assisted analysis of glycopeptides.

This study identifies O- and N-glycosylation sites on the SARS-CoV-2 spike protein and their structural motifs, revealing their potential role in proteolytic activation.

This study investigates PD-L1 glycosylation patterns and their impact on interactions with PD-1 and clinical antibodies, revealing site-specific glycan structures and potential functional implications.

This study shows that centrosome positioning is determined by actin network geometry rather than cell shape, with dynein forces placing the centrosome in an inner zone defined by actin contraction.

This study shows that vimentin intermediate filaments protect the nucleus from damage during cell migration by maintaining its shape and mechanical integrity.

The paper shows that chromatin histone modifications affect nuclear rigidity and morphology independently of lamins, inducing or suppressing nuclear blebs through changes in chromatin compaction.