Author

J. Mobbs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Organism:human· 1

Frequent Co-Authors

D. M. Thal· 2 shared H. Venugopal· 2 shared A. Christopoulos· 1 shared C. Czarnik· 1 shared C. Taveneau· 1 shared D. R. Fox· 1 shared D. Wootten· 1 shared G. Knott· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiophysics

D. M. Thal

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2 papers

Recent·Most cited

Obtaining high-resolution cryo-EM structures using a common LaB6, 120-keV electron microscope equipped with a sub 200-keV optimised direct electron detector.

H. Venugopal, J. Mobbs, C. Taveneau, D. R. Fox, Z. Vuckovic, G. Knott, R. Grinter, D. M. Thal, S. Mick, C. Czarnik, G. Ramm

This paper demonstrates that a standard 120-keV TEM with a direct electron detector can achieve high-resolution cryo-EM reconstructions of various proteins.

bioRxiv · May 26, 2024 · PreprintBiophysics

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins: insight into mechanisms of G protein selectivity

J. Mobbs, M. J. Belousoff, K. G. Harikumar, S. J. Piper, X. Xu, S. G. B. Furness, H. Venugopal, A. Christopoulos, R. Danev, D. Wootten, D. M. Thal, L. J. Miller, P. M. Sexton

The paper determines cryo-EM structures of the CCK1R bound to Gs and Gq proteins, revealing conformational changes that enable promiscuous G protein coupling.

bioRxiv · May 6, 2021Pharmacology & Toxicology