M. J. Belousoff

This paper determines the structure of a mycobacterial hydrogenase and explains how it selectively oxidizes atmospheric H2 while avoiding O2, enabling energy extraction from air.

The paper presents cryo-EM structures of the M4 mAChR with ligands and modulators, revealing structural and dynamic insights into allosteric modulation and receptor activation mechanisms.

This study presents cryo-EM structures of the PTH1R bound to various agonists, revealing how different peptides engage the receptor and providing insights for drug design.

This study discovers two novel polyglycosylated thiopeptides, persiathiacins A and B, active against drug-resistant tuberculosis and identifies their biosynthetic gene cluster.

The paper determines cryo-EM structures of the CCK1R bound to Gs and Gq proteins, revealing conformational changes that enable promiscuous G protein coupling.

The paper investigates how different GLP-1R agonists affect G protein activation kinetics through structural and functional analyses.

This study investigates how peptide agonist conformational plasticity influences GLP-1R activation through structural and functional analysis.

This study determines cryo-EM structures of GLP-1R-Gs complexes bound with semaglutide and taspoglutide, revealing similar peptide binding modes but distinct 3D motions compared to GLP-1.

This study validates stable GPCR:Gs complexes without Nb35 stabilizers and evaluates 200kV vs 300kV cryo-EM imaging for drug discovery.

This study identifies a metal-dependent dynamic equilibrium in M17 aminopeptidases from Plasmodium species that regulates hexamer formation and catalytic activity.

The paper compares the binding and activation of the GLP-1 receptor by peptide and non-peptide agonists, revealing structural and functional differences that inform drug design.

This study determines the structural basis for hormone-controlled antibiotic production in Actinobacteria by solving the X-ray structure of an MmfR-AHFCA complex and elucidating DNA release mechanisms.