Inhibition of the NLRP3 inflammasome prevents ovarian aging
J. M. Navarro-Pando, E. Alcocer-Gomez, B. Castejon-Vega, J. Muntane, C. Wang, H. M. Hoffman, A. Sanz, G. Mbalaviele, B. Ryffel, M. D. Cordero
This study shows that inhibiting the NLRP3 inflammasome improves ovarian function and fertility in aging mice by enhancing AMH, autophagy, and reducing FSH and estradiol levels.
bioRxiv · Apr 26, 2020Immunology