Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulateslipid-dependent channel activity
B. Goretzki, C. Wiedemann, B. A. McCray, S. L. Schaefer, J. Jansen, F. Tebbe, S.-A. Mitrovic, J. Noeth, J. Donohue, C. M. Jeffries, W. Steinchen, F. Stengel, C. J. Sumner, G. Hummer, U. A. Hellmich
The paper investigates how disordered regions in TRPV4 modulate channel activity through lipid-dependent interactions and identifies a conserved autoinhibitory patch that regulates PIP2 binding.
bioRxiv · Dec 21, 2022Biophysics