Author

S. L. Schaefer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Organism:human· 3 Approach:biophysical modeling· 2 Approach:experimental assay· 2 Assay:protein structure· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1

Frequent Co-Authors

G. Hummer· 5 shared A. G. Johnson· 1 shared B. A. McCray· 1 shared B. Goretzki· 1 shared C. J. Sumner· 1 shared C. M. Jeffries· 1 shared C. Wiedemann· 1 shared E. G. Margheritis· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersBiophysics

G. Hummer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structure and regulation of GSDMD pores at the plasma membrane of pyroptotic cells

S. Kappelhoff, M. Holtmannspoetter, S. L. Schaefer, E. G. Margheritis, H. Veit, J. S. H. Danial, S. Strauss, R. Franzkoch, O. E. Psathaki, R. Jungmann, R. Kurre, G. Hummer, J. Piehler, K. Cosentino

The paper visualizes GSDMD nanostructures at the plasma membrane of pyroptotic cells and identifies PI(3,4,5)P3 as a regulator of pore formation.

bioRxiv · Oct 24, 2023 · PreprintBiophysics

Structure and assembly of a bacterial gasdermin pore

A. G. Johnson, M. L. Mayer, S. L. Schaefer, N. K. McNamara-Bordewick, G. Hummer, P. J. Kranzusch

This study determines the structure of a bacterial gasdermin pore and reveals a conserved mechanism of pore assembly and membrane targeting.

bioRxiv · Apr 20, 2023Microbiology

Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulateslipid-dependent channel activity

B. Goretzki, C. Wiedemann, B. A. McCray, S. L. Schaefer, J. Jansen, F. Tebbe, S.-A. Mitrovic, J. Noeth, J. Donohue, C. M. Jeffries, W. Steinchen, F. Stengel, C. J. Sumner, G. Hummer, U. A. Hellmich

The paper investigates how disordered regions in TRPV4 modulate channel activity through lipid-dependent interactions and identifies a conserved autoinhibitory patch that regulates PIP2 binding.

bioRxiv · Dec 21, 2022Biophysics

Sublytic gasdermin-D pores captured in atomistic molecular simulations

S. L. Schaefer, G. Hummer

This study uses atomistic simulations to show that small GSDMDNT oligomers form stable, ion-conducting pores during early pyroptosis, explaining nonselective ion flux without full cell lysis.

bioRxiv · Jun 2, 2022Biophysics

Binding of SARS-CoV-2 fusion peptide to host membranes

S. L. Schaefer, H. Jung, G. Hummer

This study uses molecular dynamics simulations to show that the SARS-CoV-2 fusion peptide binds rapidly to host membranes via two amphipathic helices and can withstand mechanical forces up to 250 pN, facilitated by a conserved disulfide bridge.

bioRxiv · May 10, 2021 · PreprintBiophysics