M. Schaks

Arf GTPase activates the WAVE Regulatory Complex through a novel binding site

This study identifies a novel Arf1 binding site on WRC that drives activation through a mechanism distinct from Rac1.

Structures reveal a key mechanism of WAVE Regulatory Complex activation by Rac1 GTPase

The paper reports WAVE Regulatory Complex structures bound to Rac1, revealing how Rac1 binding at the A site activates WRC to drive actin polymerization.

Lamellipodia-like actin networks in cells lacking WAVE Regulatory Complex

The paper shows that lamellipodia-like structures can form without the WAVE Regulatory Complex by using Rac and Cdc42, but not Ena/VASP family proteins.

A structure-derived mechanism reveals how capping protein promotes nucleation in branched actin networks

This study reveals how capping protein (CP) promotes nucleation in branched actin networks by controlling access to terminal actin subunits and inhibiting nucleation promoting factors.

Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation

This study shows that lamellipodin stabilizes protrusions and promotes adhesion formation, enhancing cell migration efficiency.

Amplitude Analysis of Polarization Modulation Data and 3D-Polarization Demodulation (3D-SPoD)

This paper analyzes the amplitude of polarization modulation data in 3D-SPoD to improve structure reconstruction and reduce background noise in super-resolution imaging.

Molecular dissection of neurodevelopmental disorder-causing mutations in CYFIP2

This study investigates CYFIP2 mutations in neurodevelopmental disorders, showing most cause constitutive WRC activation, while some are loss-of-function or have minimal effects.

RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE Regulatory Complex-binding

This study shows RhoG and Cdc42 can drive lamellipodia formation independently of Rac by directly interacting with the WAVE Regulatory Complex.