Author

J. Orange

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

E. Mace· 2 shared A. Bielinsky· 1 shared A. Carisey· 1 shared A. E. Pezzi· 1 shared A. G. Heaps· 1 shared A. Padzik· 1 shared A. Stray-Pedersen· 1 shared B. D. Webb· 1 shared

Activity by Year

2017-2019 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

E. Mace

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Human NK cell deficiency as a result of biallelic mutations in MCM10

E. Mace, S. Paust, M. I. Conte, R. M. Baxley, M. Schmit, N. C. Guilz, M. Mukherjee, A. E. Pezzi, J. Chmielowiec, S. Tatineni, I. K. Chinn, Z. C. Akdemir, S. N. Jhangiani, D. M. Muzny, A. Stray-Pedersen, , J. Orange

This study identifies biallelic MCM10 mutations as a cause of human NK cell deficiency, showing impaired NK cell maturation and function in a patient with CMV susceptibility.

bioRxiv · Nov 7, 2019Immunology

Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Transcriptional and Biochemical Function

C. N. Gruber, J. Calis, S. Buta, G. Evrony, J. C. Martin, S. Uhl, R. Caron, L. Jarchin, D. Dunkin, R. Phelps, B. D. Webb, J. Saland, M. Merad, J. Orange, E. M. Mace, , D. Bogunovic

This study identifies a JAK1 mutation causing autoinflammation and shows its unique transcriptional and functional effects through single-cell analysis and clinical treatment.

bioRxiv · Oct 17, 2019Immunology

Demultiplexing overlapping signaling scaffold functions to probe lipid messenger coupling to cytoskeletal dynamics.

N. J. Trenton, R. T. McLaughlin, S. Bellamkonda, D. Tsao, E. Mace, j. orange, V. Schweikhard, M. R. Diehl

This study uses live-cell imaging and statistical analyses to show IQGAP1 regulates actin dynamics around endosomes through PIP3-dependent tethering and transient inhibition of actin growth.

bioRxiv · Jun 14, 2019 · PreprintBiophysics

FiloQuant reveals increased filopodia density during DCIS progression

G. Jacquemet, I. Paatero, A. Carisey, A. Padzik, J. Orange, H. Hamidi, J. Ivaska

FiloQuant quantifies filopodia density and dynamics in various cell types and microenvironments, revealing increased filopodia density during DCIS progression.

bioRxiv · Apr 6, 2017Cell Biology