E. Mace

Seminal root angle is associated with root system architecture in durum wheat

This study examines the relationship between seminal root angle and root system architecture in durum wheat, showing distinct RSA patterns in wide and narrow genotypes at later growth stages.

CD56/NCAM mediates cell migration of human NK cells by promoting integrin-mediated adhesion turnover

This study shows CD56/NCAM is essential for human NK cell migration by modulating actin dynamics and integrin turnover during movement on stromal cells.

Efficient and sustained optogenetic control of sensory and cardiac systems

This paper introduces ChReef, an improved optogenetic tool with enhanced performance in sensory and cardiac systems, demonstrating its effectiveness in restoring visual and auditory function.

Replication stress in activated human NK cells induces sensitivity to apoptosis

This study shows that replication stress in activated human NK cells increases apoptosis and impairs function, linking helicase deficiency to NK cell deficiency.

Genetic diversity analysis and characterization of Ugandan sorghum

This study characterizes Ugandan sorghum genetic diversity using whole genome SNPs and identifies genomic regions associated with juvenile cold tolerance for breeding improvement.

CD56 regulates human NK cell cytotoxicity through Pyk2

This study shows CD56 enhances NK cell cytotoxicity by promoting exocytosis and signaling through Pyk2 phosphorylation.

Human NK cell deficiency as a result of biallelic mutations in MCM10

This study identifies biallelic MCM10 mutations as a cause of human NK cell deficiency, showing impaired NK cell maturation and function in a patient with CMV susceptibility.

Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity

This study identifies DNA hyper-methylation in immune-related pathways of TB patients, leading to reduced immune responsiveness to mycobacterial antigens.

Demultiplexing overlapping signaling scaffold functions to probe lipid messenger coupling to cytoskeletal dynamics.

This study uses live-cell imaging and statistical analyses to show IQGAP1 regulates actin dynamics around endosomes through PIP3-dependent tethering and transient inhibition of actin growth.

A domestication history of dynamic adaptation and genomic deterioration in sorghum

This study analyzes archaeogenomes of sorghum to show a decline in genetic diversity and mutation load over time, with dynamic selection pressures and introgression shaping domestication.