Author

D. Bogunovic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2

Frequent Co-Authors

J. Taft· 5 shared M. Martin-Fernandez· 5 shared S. Buta· 5 shared K. Niazi· 3 shared P. Soon-Shiong· 3 shared R. S. Patel· 3 shared S. Rabizadeh· 3 shared S. Tanaka· 3 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersImmunology

J. Taft

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Author profile →

8 papers

Recent·Most cited

Broad-spectrum RNA antiviral inspired by ISG15-/- deficiency

Y. T. Akalu, R. S. Patel, J. Taft, R. Canas-Arranz, A. Richardson, S. Buta, M. Martin-Fernandez, C. Sazeides, R. L. Pearl, G. Mainkar, A. P. Kurland, R. Geltman, H. Rosberger, D. D. Kang, A. A. Kurian, , D. Bogunovic

The paper identifies a set of 10 ISGs that confer broad-spectrum antiviral resistance and demonstrates their efficacy in protecting against multiple viruses in vivo.

bioRxiv · Jun 24, 2024 · PreprintImmunology

Rapid Identification of Neutralizing Antibodies against SARS-CoV-2 Variants by mRNA Display

S. Tanaka, C. A. Olson, C. O. Barnes, W. Higashide, M. Gonzales, J. Taft, A. Richardson, M. Martin-Fernandez, D. Bogunovic, P. N. P. Gnanapragasam, P. Bjorkman, P. R. Spilman, K. Niazi, S. Rabizadeh, P. Soon-Shiong

This study uses mRNA display to identify and engineer neutralizing antibodies against SARS-CoV-2 variants, revealing binding modes and demonstrating their effectiveness against mutations in the spike protein.

bioRxiv · Sep 14, 2021Immunology

A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signalling

A. Vasou, K. Nightingale, V. Cetkovska, J. Scheler, C. G. Bamford, J. Andrejeva, U. Schwarz-Linek, R. E. Randall, J. McLauchlan, M. P. Weekes, D. Bogunovic, D. J. Hughes

The paper identifies a new function of ISG15 in stabilizing USP18 through non-covalent interactions, revealing a mechanism that controls type I IFN signalling.

bioRxiv · Jun 1, 2021 · PreprintImmunology

The Dual-Antigen Ad5 COVID-19 Vaccine Delivered as an Intranasal Plus Subcutaneous Prime Elicits Th1 Dominant T-Cell and Humoral Responses in CD-1 Mice

A. Rice, M. Verma, A. Shin, L. Zakin, P. Sieling, S. Tanaka, J. Balint, K. Dinkins, H. Adisetiyo, B. Morimoto, W. Higashide, J. Taft, R. S. Patel, S. Buta, M. Martin-Fernandez, , P. Soon-Shiong

This study evaluates a dual-antigen Ad5 vaccine delivered via subcutaneous and intranasal routes in mice, showing that combined prime-only delivery elicits strong humoral and T-cell responses against SARS-CoV-2.

bioRxiv · Mar 22, 2021Immunology

Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria

R. Yang, F. Mele, L. Worley, D. Langlais, J. Rosain, I. Benhsaien, H. Elarabi, C. A. Croft, J.-M. Doisne, P. Zhang, M. Weisshaar, D. Jarrossay, D. Latorre, Y. Shen, J. Han, , L. H Glimcher

This study identifies T-bet deficiency as a cause of mycobacterial disease by impairing IFN-γ production in innate and innate-like adaptive lymphocytes.

bioRxiv · Aug 31, 2020Immunology

A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses

A. Rice, M. Verma, A. Shin, L. Zakin, P. Sieling, S. Tanaka, H. Adisetiyo, J. Taft, R. S. Patel, S. Buta, M. Martin-Fernandez, B. Morimoto, E. Gabitzsch, J. T. Safrit, J. Balint, , P. Soon-Shiong

This paper describes a bivalent hAd5 vaccine combining S-Fusion and N-ETSD antigens that elicits strong Th1-biased T-cell and neutralizing antibody responses in pre-clinical models.

bioRxiv · Jul 29, 2020 · PreprintImmunology

Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy

C. N. Gruber, M. Martin-Fernandez, F. Ailal, X. Qiu, J. Taft, J. Altman, J. Rosain, S. Buta, A. Bousfiha, J.-L. Casanova, J. Bustamante, D. Bogunovic

The paper identifies a homozygous STAT2 mutation causing type I interferonopathy by disrupting USP18 interaction and signal termination.

bioRxiv · Dec 12, 2019Immunology

Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Transcriptional and Biochemical Function

C. N. Gruber, J. Calis, S. Buta, G. Evrony, J. C. Martin, S. Uhl, R. Caron, L. Jarchin, D. Dunkin, R. Phelps, B. D. Webb, J. Saland, M. Merad, J. Orange, E. M. Mace, , D. Bogunovic

This study identifies a JAK1 mutation causing autoinflammation and shows its unique transcriptional and functional effects through single-cell analysis and clinical treatment.

bioRxiv · Oct 17, 2019Immunology