Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4+ T cell response
A. Chudnovskiy, T. B. Castro, S. Nakandakari-Higa, A. Cui, C.-H. Lin, M. Sade-Feldman, B. K. Phillips, J. Pae, L. Mesin, J. Bortolatto, L. D. Schweitzer, G. Pasqual, L.-F. Lu, N. Hacohen, G. D. Victora
The paper identifies dendritic cells that present antigens to CD4+ T cells in tumor-draining lymph nodes and the tumor microenvironment using LIPSTIC-based single-cell transcriptomics.
bioRxiv · Oct 25, 2022Immunology