L.-F. Lu

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

This study shows that fish CDK2 recruits Dtx4 to ubiquitinate and degrade TBK1, reducing IFN expression and enhancing antiviral resistance.

Intronic miR342 is a master regulator of cellular glycolysis in Foxp3+ regulatory CD4 T cells

This study identifies miR-342 as a master regulator of glycolysis in Foxp3+ regulatory T cells, essential for controlling inflammation in the central nervous system.

Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity

This study identifies intestinal regulatory T cells producing IL-27 to specifically regulate Th17 immunity in the gut, revealing a novel mechanism for tissue-specific immune control.

Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4+ T cell response

The paper identifies dendritic cells that present antigens to CD4+ T cells in tumor-draining lymph nodes and the tumor microenvironment using LIPSTIC-based single-cell transcriptomics.

Transcriptomes and metabolism define mouse and human MAIT cell heterogeneity

This study identifies MAIT cell heterogeneity in mice and humans through single-cell RNA sequencing and metabolic analysis, revealing distinct transcriptomes and metabolic states in different tissues and species.

Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS-TBK1 Activation .

This paper identifies how GCRV proteins interact with fish RLR factors to suppress MAVS-TBK1 signaling and reduce IFN expression, revealing a unique fish virus evasion mechanism.

PD-L1:CD80 Heterodimer Triggers CD28 While Repressing Both PD-1 and CTLA4 Pathways

The paper identifies a molecular crosstalk where PD-L1 and CD80 form a heterodimer, blocking inhibitory pathways but preserving CD28 activation, and shows how PD-L1 blockade affects CD80 expression.