A. Melnick

Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress

This study identifies Cdc73 as a Notch cofactor that protects T-ALL cells from DNA damage and mitochondrial stress by intersecting with Notch at chromatin to activate oncogenes and repair pathways.

Profiling Dynamic Patterns of Single-cell Motility

This study introduces CaMI, a framework to classify single-cell motility patterns, revealing heterogeneity and dynamics not captured by traditional ensemble methods.

Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells

This study identifies cyclin D3 as essential for inertial cell cycling in dark zone germinal center B cells, enabling clonal expansion and linking it to potential lymphoproliferative disorders.

Cell-free DNA (cfDNA) and exosome profiling from a year-long humanspaceflight reveals circulating biomarkers

This study profiles cfDNA and exosomes from an astronaut during a year-long spaceflight, identifying increased cf-mtDNA and exosomal brain-derived peptides as potential biomarkers of spaceflight-related stress.

KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas

This study shows that inhibiting KDM5 demethylases restores H3K4 methylation and reactivates genes in KMT2D mutant lymphomas, offering a potential therapeutic strategy.

Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma

The paper identifies aberrant chromatin activation as a common mechanism driving the malignant phenotype in multiple myeloma.

Selective inhibition of HDAC3 targets synthetic vulnerabilities and activates immune surveillance in lymphoma

This paper shows that HDAC3 inhibitors reverse CREBBP mutation-driven epigenetic changes in lymphoma, inhibiting tumor growth and restoring immune surveillance.