D. Becher

Transformation of the drug ibuprofen by Priestia megaterium: Reversible glycosylation and generation of hydroxylated metabolites

This paper identifies two main biotransformation pathways of ibuprofen by Priestia megaterium, including hydroxylation and reversible glycosylation, and shows their potential role in detoxification.

The microbiome of the lichen Lobaria pulmonaria varies according to climate in Europe

This study examines how the bacterial microbiome of the lichen Lobaria pulmonaria varies with climate across Europe, finding that climatic factors explain more variation than local weather or sampling season.

Metaproteogenomics resolution of a high-CO2 aquifer community suggests an active symbiotic lifestyle of groundwater Gracilibacteria

The paper investigates Gracilibacteria activity in a high-CO2 aquifer using metaproteogenomics, suggesting they may function as microbial predators.

Homologs of the plastidal preprotein translocase Tic20 mediate organelle assembly in bacteria

The paper identifies MamF-like proteins in bacteria as homologs of the chloroplast Tic20 translocase, showing they mediate magnetosome assembly and function.

Novel laminarin-binding CBMs in multimodular proteins of marine Bacteroidota feature prominently in phytoplankton blooms

The paper identifies and characterizes novel laminarin-binding CBMs in marine Bacteroidota, showing their prevalence in phytoplankton blooms.

The large GTPase Sey1/atlastin mediates lipid droplet- and FadL-dependent intracellular fatty acid metabolism of Legionella pneumophila

This paper shows that Sey1 facilitates lipid droplet and FadL-dependent fatty acid metabolism in Legionella pneumophila by promoting interactions between the Legionella-containing vacuole and lipid droplets.

The Legionella-driven PtdIns(4)P gradient at LCV-ER membrane contact sites promotes Vap-, OSBP- and Sac1-dependent pathogen vacuole remodeling

Marine particle microbiomes during a spring diatom bloom contain active sulfate-reducing bacteria

The paper analyzes marine particle microbiomes during a spring diatom bloom and identifies active sulfate-reducing bacteria in the particulate fraction.

Alterations of oral microbiota and impact on the gut microbiome in type 1 diabetes mellitus revealed by multi-omic analysis

This study identifies oral microbiota changes in T1DM linked to gut microbiome alterations through multi-omic analysis of saliva and stool samples.

Expression of the cyanobacterial F0F1 ATP synthase inhibitor Atp{Theta} depends on small basic DNA-binding proteins and differential mRNA stability

This study identifies transcriptional and posttranscriptional regulators of atpT gene expression in Synechocystis sp. PCC 6803, showing mRNA stability is the major factor controlling Atp{Theta} expression under different conditions.

Atp{Theta} is an inhibitor of F0F1 ATP synthase to arrest ATP hydrolysis during low-energy conditions in cyanobacteria

This study identifies Atp{Theta} as an inhibitor of F0F1 ATP synthase in cyanobacteria, preventing ATP hydrolysis under low-energy conditions.

CdrS is a global transcriptional regulator influencing cell division in Haloferax volcanii

This study identifies CdrS as a transcriptional regulator essential for cell division in Haloferax volcanii, showing it influences metabolism, protein degradation, and cell division genes.

Extensive transfer of genes for edible seaweed digestion from marine to human gut bacteria

The paper shows gut bacteria have extensively adapted to digest seaweed polysaccharides through gene transfer from marine bacteria, revealing widespread metabolic plasticity in the human gut microbiome.

A global data-driven census of Salmonella small proteins and their potential functions in bacterial virulence

The paper identifies and characterizes small proteins in Salmonella Typhimurium using integrated omics data, revealing a new role for MgrB in virulence and motility.

Metabolic differences between symbiont subpopulations in the deep-sea tubeworm Riftia pachyptila

The paper identifies metabolic differences between symbiont subpopulations in Riftia pachyptila, showing small symbionts focus on division and host interaction while large ones specialize in carbon fixation and biosynthesis.

The bacterial leader peptide peTrpL has a conserved function in antibiotic-dependent posttranscriptional regulation of ribosomal genes

The paper identifies peTrpL as a conserved bacterial leader peptide that, along with rnTrpL, mediates tetracycline-dependent destabilization of ribosomal protein mRNAs.

Peptide-based quorum sensing systems in Paenibacillus polymyxa

The paper identifies 16 peptide-based quorum sensing systems in Paenibacillus polymyxa and shows their conservation across the Paenibacillaceae family.

Characterization of a thaumarchaeal symbiont that drives incomplete nitrification in the tropical sponge Ianthella basta

This paper characterizes a thaumarchaeal symbiont in the sponge Ianthella basta, showing it is the sole ammonia-oxidizer and reveals adaptations for a mixotrophic lifestyle.

Subtractive Interaction Proteomics Reveal a Network of Signaling Pathways Activated by an Oncogenic Transcription Factor in Acute Myeloid Leukemia

This study uses subtractive interaction proteomics to identify signaling pathways activated by the t(6;9)-DEK/CAN oncogene in AML, revealing potential therapeutic targets.