Author

J. Polmear

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:scATAC-seq· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. Fletcher· 1 shared A. Nguyen· 1 shared C. D. Scharer· 1 shared C. Szeto· 1 shared E. L'Estrange-Stranieri· 1 shared E. S. Pang· 1 shared H. Xu· 1 shared I. A. Parish· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

A. Fletcher

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Author profile →

2 papers

Recent·Most cited

Targeting BMI-1 to deplete antibody-secreting cells in autoimmunity

J. Polmear, L. Hailes, M. Olshansky, M. Rischmueller, E. L'Estrange-Stranieri, A. Fletcher, M. Hibbs, V. Bryant, K. Good-Jacobson

This study shows that inhibiting BMI-1 reduces antibody-secreting cells in autoimmune models, suggesting BMI-1 as a therapeutic target for antibody-mediated autoimmune diseases.

bioRxiv · Jul 27, 2023Immunology

Type I interferon dynamics determines memory B cell epigenetic identity in chronic viral infection

L. Cooper, H. Xu, J. Polmear, C. Szeto, E. S. Pang, M. Gupta, J. J. Taylor, K. J. L. Jackson, A. Nguyen, N. La Gruta, L. G. Martelotto, I. A. Parish, M. O'Keeffe, C. D. Scharer, S. Gras, K. L. Good-Jacobson

The paper identifies type I interferon dynamics as a key factor shaping memory B cell development during chronic viral infection and shows that early IFNAR-1 blockade can reverse chromatin changes.

bioRxiv · Mar 2, 2023Immunology