Author

A. Fletcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. J. McCabe· 3 shared H. R. Nieto· 3 shared K. Boelaert· 3 shared K. Brookes· 3 shared M. L. Read· 3 shared V. E. Smith· 3 shared C. E. M. Thornton· 2 shared M. Alshahrani· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

C. J. McCabe

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Delay of innate immune responses following influenza B virus infection affects the development of robust antibody response in ferrets

T. Rowe, A. Fletcher, R. A. Richardson, M. Lange, G. A. Sautto, G. A. Kirchenbaum, Y. Hatta, G. Jasso, D. E. Wentworth, T. M. Ross

This study shows that delayed innate immune responses to influenza B virus in ferrets lead to weaker antibody responses compared to influenza A virus.

bioRxiv · Feb 19, 2024Microbiology

Targeting BMI-1 to deplete antibody-secreting cells in autoimmunity

J. Polmear, L. Hailes, M. Olshansky, M. Rischmueller, E. L'Estrange-Stranieri, A. Fletcher, M. Hibbs, V. Bryant, K. Good-Jacobson

This study shows that inhibiting BMI-1 reduces antibody-secreting cells in autoimmune models, suggesting BMI-1 as a therapeutic target for antibody-mediated autoimmune diseases.

bioRxiv · Jul 27, 2023Immunology

Dissecting endocytic mechanisms reveals new molecular targets to enhance sodium iodide symporter activity with clinical relevance to radioiodide therapy

M. L. Read, K. Brookes, L. Zha, S. Manivannan, J. Kim, M. Kocbiyik, A. Fletcher, C. M. Gorvin, G. Firth, G. O. Fruhwirth, J. P. Nicola, S. Jhiang, M. D. Ringel, M. J. Campbell, K. Sunassee, , C. J. McCabe

This study identifies an acidic dipeptide in NIS that mediates AP2 binding, showing chloroquine enhances NIS membrane retention and RAI uptake in thyroid cancer.

bioRxiv · May 22, 2023 · PreprintCancer Biology

Digital Spatial Profiling of Intraductal Papillary Mucinous Neoplasms: Towards a Molecular Framework for Risk Stratification

P. J. Allen, M. K. Iyer, C. Shi, A. M. Eckhoff, A. Fletcher, D. P. Nussbaum

The paper uses spatial RNA profiling to identify molecular markers and insights into malignant progression in intraductal papillary mucinous neoplasms (IPMN).

bioRxiv · Sep 8, 2022Cancer Biology

New mechanisms of radioiodide uptake revealed via a novel high throughput drug screening approach in thyroid cancer

M. L. Read, K. Brookes, C. E. M. Thornton, A. Fletcher, M. Alshahrani, R. Khan, H. R. Nieto, P. Borges de Souza, J. R. M. Webster, L. J. Alderwick, K. Boelaert, V. E. Smith, C. J. McCabe

This study identifies FDA-approved drugs that enhance radioiodide uptake through non-canonical NIS processing pathways, revealing new therapeutic strategies for thyroid cancer.

bioRxiv · Jul 21, 2020 · PreprintCancer Biology

Pharmacologically targeting a novel pathway of sodium iodide symporter trafficking to enhance radioiodine uptake

A. Fletcher, M. L. Read, C. E. M. Thornton, D. P. Larner, V. L. Poole, K. Brookes, H. R. Nieto, M. Alshahrani, R. J. Thompson, G. G. Lavery, M. J. Campbell, K. Boelaert, A. S. Turnell, V. E. Smith, C. J. McCabe

This study identifies ARF4 and VCP as regulators of NIS trafficking and shows FDA-approved VCP inhibitors enhance radioiodine uptake in thyroid cancer cells and mice.

bioRxiv · May 7, 2019 · PreprintCancer Biology

Morphological plant modeling: Unleashing geometric and topological potential within the plant sciences

A. Bucksch, A. Atta-Boateng, A. F. Azihou, M. Balduzzi, D. Battogtokh, A. Baumgartner, B. Binder, S. Braybrook, C. Chang, V. Coneva, T. DeWitt, A. Fletcher, M. Gehan, D. Hernan Diaz Martinez, L. Hong, , D. Chitwood

This paper discusses the importance of mathematical modeling in plant morphology and outlines challenges and opportunities for integrating geometric and topological approaches in plant science research and education.

bioRxiv · Feb 8, 2017Plant Biology