Defining totipotency using criteria of increasing stringency
E. Posfai, J. P. Schell, A. Janiszewski, I. Rovic, A. Murray, B. Bradshaw, T. Pardon, M. El Bakkali, I. Talon, N. De Geest, P. Kumar, S. K. To, S. Petropoulos, A. Jurisicova, V. Pasque, , J. Rossant
The paper defines totipotency using increasing stringency criteria and evaluates candidate cell types in mice, finding that expanded pluripotent states do not show higher totipotency than conventional embryonic stem cells under in vivo conditions.
bioRxiv · Mar 2, 2020 · PreprintCell Biology