Author

L. Pinello

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Choudhary· 1 shared A. Ralston· 1 shared A. Regev· 1 shared B. Becerra· 1 shared B. K. Law· 1 shared B. L. Ebert· 1 shared C. Fulco· 1 shared C. M.-C. Li· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperBioengineering

A. Choudhary

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Novel mechanism of MYC deregulation in Multiple Myeloma

M. Rahmat, K. Clement, J.-B. Alberge, R. Sklavenitis-Pistofidis, R. Kodgule, C. Fulco, D. Heilpern-Mallory, K. Nilsson, D. Dorfman, J. Engreitz, G. Getz, L. Pinello, R. Ryan, I. M. Ghobrial

The paper identifies a new epigenetic mechanism of MYC deregulation in multiple myeloma through enhancer accessibility and transcription factor binding, independent of translocations or amplifications.

bioRxiv · May 19, 2023 · PreprintCancer Biology

A molecular glue approach to control the half-life of CRISPR-based technologies

V. Sreekanth, M. Jan, K. T. Zhao, D. Lim, J. R. Davis, M. McConkey, V. Kovalcik, S. Barkal, B. K. Law, J. Fife, R. Tian, M. E. Vinyard, B. Becerra, M. E. Kampmann, R. I. Sherwood, , A. Choudhary

This paper introduces a molecular glue approach using pomalidomide to control the half-life of CRISPR-based technologies, enabling precise regulation of their activity and therapeutic potential.

bioRxiv · Mar 12, 2023Bioengineering

Aging-associated alterations in the mammary gland revealed by single-cell RNA sequencing

C. M.-C. Li, H. Shapiro, C. Tsiobikas, L. Selfors, H. Chen, G. K. Gray, Y. Oren, L. Pinello, A. Regev, J. S. Brugge

This study uses scRNA-seq to analyze aging effects on mammary gland cell populations in mice, identifying age-related gene expression changes and a decline in a specific luminal cell subset.

bioRxiv · Sep 18, 2019Cell Biology

The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during trophectoderm and inner cell mass specification

D. Huang, X. Han, P. Yuan, A. Ralston, L. Sun, M. Huss, T. Mistri, L. Pinello, H. H. Ng, G. Yuan, J. Ji, J. Rossant, P. Robson, G. Guo

This study identifies CDX2-regulated genes and regulatory elements in mouse embryos, revealing how CDX2 represses pluripotent genes during trophectoderm and inner cell mass specification.

bioRxiv · Apr 6, 2017Cell Biology