Author

J. Rouse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

R. Toth· 3 shared F. Brown· 2 shared F. Lamoliatte· 2 shared F. Weiland· 2 shared H. Zhou· 2 shared I. Munoz· 2 shared T. Carroll· 2 shared T. Macartney· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersBiochemistry

R. Toth

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Chemo-phosphoproteomic profiling with ATR inhibitors berzosertib and gartisertib uncovers new biomarkers and DNA damage response regulators

R. S. Jadav, F. Weiland, S. M. Noordermeer, T. Carroll, Y. Gao, J. Wang, H. Zhou, F. Lamoliatte, I. Munoz, R. Toth, T. Macartney, F. Brown, C. J. Hastie, C. Alabert, H. van Attikum, , J. Rouse

The paper identifies novel ATR-dependent phospho-proteomic targets and reveals new biomarkers and genome maintenance factors through screening with ATR inhibitors.

bioRxiv · Apr 3, 2023Biochemistry

Interaction with C21ORF2 controls the cellular functions of the NEK1 kinase

J. Rouse, M. Gregorczyk, G. Pastore, P. Lis, S. Lange, F. Lamoliatte, T. Macartney, R. Toth, F. Brown, J. Hastie, D. Durocher

This study identifies C21ORF2 as a regulatory subunit of NEK1, showing that their interaction is critical for NEK1 function and that mutations disrupt this interaction, linking it to disease.

bioRxiv · Aug 31, 2022 · PreprintBiochemistry

Epilepsy kinase CDKL5 is a DNA damage sensor which controls transcriptional activity at DNA breaks

T. Khanam, I. Munoz, F. Weiland, T. Carroll, B. N. Borsos, V. Pantazi, M. Slean, M. Novak, R. Toth, P. Appleton, T. Pankotai, H. Zhou, J. Rouse

CDKL5 is a DNA damage-sensing kinase that modulates transcriptional activity near DNA breaks.

bioRxiv · Dec 10, 2020 · PreprintCell Biology