J. S. Ayres

This study shows fluoxetine protects against sepsis by increasing IL-10, which prevents metabolic issues in the heart.

This study shows that age affects disease tolerance mechanisms in sepsis, with a cardioprotective pathway in young mice causing heart damage in older mice.

The paper shows physiological defenses and immune resistance work together to allow asymptomatic carriage of a lethal bacterial pathogen.

This study identifies CD4+ T cells as regulators of sickness-induced anorexia and fat wasting during a chronic parasitic infection, revealing a decoupling between immune resistance and cachexia.

This study shows that fat-specific adipose triglyceride lipase is required for iron-induced lipolysis and lipid mobilization during negative energy balance.

This study shows that leptin signaling inhibition protects against Yersinia pseudotuberculosis infection by increasing host-pathogen cooperation, not resistance, through increased liver damage and dysfunction.

The paper identifies an E. coli strain that affects maternal behavior through microbiota-host interactions, leading to offspring growth stunting via impaired IGF-1 signaling.