J. S. Brugge

The paper shows that BRCA2-mutant mammary epithelial cells with low hormone receptor expression expand under replication stress through a transcriptional response involving Tspan8 and Thrsp.

The paper identifies cycling cancer persisters with distinct transcriptional and metabolic programs using a new tracing system and shows that targeting oxidative stress or metabolic reprogramming reduces their fraction.

This study uses scRNA-seq to analyze aging effects on mammary gland cell populations in mice, identifying age-related gene expression changes and a decline in a specific luminal cell subset.

The paper investigates how Akt regulates glycolysis to maintain metabolic stability in proliferating human cells through single-cell dynamics analysis.

This paper introduces DNA-Exchange-Imaging, a method for rapid, highly multiplexed in situ protein visualization, achieving sub-20 nm resolution and reducing imaging time from days to minutes.