Pharmacology & ToxicologybioRxiv
The Lonidamine Derivative H2-Gamendazole Reduces Cyst Formation in Polycystic Kidney Disease
S. V. Sundar, X. Zhou, B. S. Magenheimer…·J. P. Calvet
This study shows that H2-GMZ reduces cyst formation in ADPKD by inhibiting Cl- secretion, cell proliferation, and motility in both in vitro and in vivo models.