J. Sarathy

Macrophage internalization creates a multidrug-tolerant fungal persister population, providing a permissive reservoir for the emergence of drug resistance

This study shows that macrophage internalization creates drug-tolerant C. glabrata persisters, which can give rise to drug-resistant mutants, and that amphotericin B can kill these persisters.

Pyrazinamide triggers degradation of its target aspartate decarboxylase

This paper shows that pyrazinamide's active form, POA, triggers degradation of its target enzyme PanD via the ClpC1-ClpP protease, rather than inhibiting it directly.