T. Dick

Postural adaptations may contribute to the unique locomotor energetics seen in hopping kangaroos

This study uses a 3D musculoskeletal model to analyze how hindlimb posture affects tendon stress and energy storage in hopping kangaroos, revealing posture-mediated elastic energy savings.

Mycobacterium tuberculosis DprE1 inhibitor OPC-167832 is active against Mycobacterium abscessus in vitro

OPC-167832, a DprE1 inhibitor active against Mycobacterium tuberculosis, shows in vitro activity against Mycobacterium abscessus but lacks efficacy in a mouse model due to moderate potency.

Strongly bactericidal all-oral β-lactam combinations for the treatment of Mycobacterium abscessus lung disease

The paper evaluates oral β-lactam combinations with avibactam against Mycobacterium abscessus and identifies synergistic bactericidal effects.

Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus

This study evaluates the activity of TPP8, a tricyclic pyrrolopyrimidine gyrase B inhibitor, against Mycobacterium abscessus in vitro, ex vivo, and in vivo.

Pyrazinamide triggers degradation of its target aspartate decarboxylase

This paper shows that pyrazinamide's active form, POA, triggers degradation of its target enzyme PanD via the ClpC1-ClpP protease, rather than inhibiting it directly.

Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance

This paper identifies a novel mechanism of drug tolerance in M. tuberculosis through phase variation in the glpK gene, showing reversible frameshift mutations that contribute to treatment failure and relapse.

Identification of new MmpL3 inhibitors by untargeted and targeted mutant screens defines MmpL3 domains with differential resistance

The paper identifies new MmpL3 inhibitors through screens and analyzes resistance mutations to define clades of inhibitors and mutants with differential resistance.